The belief in the Darwinian theory of evolution appeared to be shaken when one tried to interpret statements of molecular biology in it. As a consequence there arose a theory of non-Darwinian neutral evolution. The supporters of this theory believe that under natural conditions no factors exist which can distinguish and select organisms on their internal (molecular) structure. In the opinion of these neutralists natural selection cannot in principle control the molecular constitution of organisms. Contrary to the viewpoint of the (...) critics of neutralism it is impossible to admit that nucleic acids, proteins and other biomolecules can evolve without the participation of natural selection. This controversy in contemporary theoretical biology can be solved by integrating the conceptions of molecular ecology with Darwinian theory. Molecular ecology acknowledges the interactions of organisms by means of chemical substances synthesized by them. Such chemical ecological factors play a leading part in the selective stages of biomolecular evolution. These diverse chemical ecological interrelations take place intensively when living beings interact with parasitic microbes. (shrink)

The formalism of general probabilistic theories provides a universal paradigm that is suitable for describing various physical systems including classical and quantum ones as particular cases. Contrary to the usual no-restriction hypothesis, the set of accessible meters within a given theory can be limited for different reasons, and this raises a question of what restrictions on meters are operationally relevant. We argue that all operational restrictions must be closed under simulation, where the simulation scheme involves mixing and classical post-processing of (...) meters. We distinguish three classes of such operational restrictions: restrictions on meters originating from restrictions on effects; restrictions on meters that do not restrict the set of effects in any way; and all other restrictions. We fully characterize the first class of restrictions and discuss its connection to convex effect subalgebras. We show that the restrictions belonging to the second class can impose severe physical limitations despite the fact that all effects are accessible, which takes place, e.g., in the unambiguous discrimination of pure quantum states via effectively dichotomic meters. We further demonstrate that there are physically meaningful restrictions that fall into the third class. The presented study of operational restrictions provides a better understanding on how accessible measurements modify general probabilistic theories and quantum theory in particular. (shrink)

This article aims to demonstrate the unity of faith and reason as irrational and rational elements of the theoretical religious discourse on instances of Christian theoretical thought. This unity was represented as a dialectical contradiction, the violation of which led to the destruction of religious discourse. The contradictory unity of faith and reason was researched in European medieval philosophy and Russian religious philosophy in the first half of the 20th century and in the theoretical systems that were considered ways of (...) explaining the relationship between faith and reason in Christian thought. This article reveals two historical types of the dynamic unity of faith and reason as well as violations of this unity: when medieval authors attempted to find the most effective relationship between faith and reason for Christian theology; and when Russian philosophers attempted to transmit theological knowledge by means of philosophy in the secular age. The results of the dynamic unity violations in both traditions are investigated as the conceptions that had been denied by these traditions. The main conclusion of the article is that Christian theoretical thought maintained the contradictions between faith and reason as a search for its development. (shrink)

The philosophical definition of violence today is “incomplete” and leaves a “gap” between the phenomenon and the concept. This is due to the fact that the concept of “violence” was/is strangely included in the general philosophical categorial line. In domestic and Western discourse, the problem field of violence contains, above all, political and ethical meanings. The problem is intuitively resolved in its appeal to the concept of “power”, which turns out to be philosophically lost in modern philosophy. Only exceptionally do (...) we find “traces” of this concept in philosophical works. Among them are the works of Aristotle, which need to be freed from modern, distorting interpretations. Thus, in the translations of Aristotle, the Greek δύναμις, used for the traditional transferring the category of possibility, lost its meaning of force ; in its turn, “force” lost relation to “violence” and “necessity”. Violence is understood as a kind of necessity, which is associated with the suppression of one’s “own decision”, freedom, something that “prevents desire” and contrary to “common thinking,” as well as the absence of “good”. Violence is presented not only in an ontological sense, but also existentially, as the opposite of “good” and of one’s own “desire”. Force remains in the shadow of “necessity” as “possibility”, “potential energy” and “movement”, and violence loses the opposition that has arisen in an ontological mode. (shrink)

In the course of a close analysis of Kant’s essay in which he gives his original answer to the question, “What is Enlightenment?” I examine the causes and consequences of the theses about Enlightenment which makes a plea for emancipation from the shackles of guardianship, above all by getting rid of one’s own cowardice. In search of an answer to the question, “What is the real reason of self-incurred immaturity?” I consider the bifurcation: Is it all about unjust social institutions (...) established in the interests of the ruling social estates, as the best European brains contended throughout the Enlightenment era, thus anticipating and justifying revolutionary upheavals, or is it within ourselves who have refused to use our reason independently and regularly? — something which Kant unequivocally considers to be everyone’s special kind of guilt. Following Kant, I look for an answer to the question, “Which limits impede Enlightenment, and which limits, far from obstructing it, are bound to promote it?” and reveal the hidden paradox of the Kantian solution: maturity has to be preceded by the granting of freedoms; and the granting of freedoms in turn calls for a mature public. I also ask the question, “Whose yoke is heavier, one’s own or the guardian’s?” and offer my version of an answer. In conclusion, I assemble all parts of the complicated and original formula of the Kantian recipe of Enlightenment. Among other things, I reveal a special type of bonding within the social organism implied by Kant, and that is the requirement to obey those who are not above us in thinking and the right to speak out in public, which ultimately means not only personal maturity, but implies also the maturity of society’s functioning in accordance with the said maxim. (shrink)

This essay serves as an intellectual biographical introduction to the special issue devoted to one of the leading Russian contemporary philosophers, Vyacheclav S. Stepin. The essay discusses Stepin's philosophical works and his chief contributions to such fields as philosophy and methodology of science, epistemology, and philosophical ontology among others. The authors also reflect on Stepin's academic leadership and his role as an organizer of research in philosophy in the contemporary Russia.

The study contains the review, analysis, assessment of the current state and prospects for further scientific study of the materials of the Russian state archives, including the personal funds of philosophers and philosophical institutions of Russia in the 19th-20th centuries, which are of the greatest relevance to historians of Russian philosophy. In this regard, on the one hand, the study considers the largest research and scientific-publishing historical and philosophical projects, testifying to the already achieved results of the scientific development of (...) vast arrays of archival documents; on the other hand, a number of collections of Russian state archives (federal, regional, municipal, departmental) have been monitored in order to identify archival collections that were little or insufficiently studied from this point of view. The results of the collective research presented in the article can be considered as the beginning of a large systematic work on the analytical mapping of the content of Russian archival collections relevant to the problems of the history of Russian philosophy. The study shows the importance and productivity of conducting parallel research work both with the personal funds of Russian philosophers of the 19th-20th centuries, and with funds containing documentation of philosophical institutions (magazine editorial offices, faculties, departments, research institutes, publishing houses of philosophical literature, professional and thematic associations of philosophers). In this regard, the question was raised about the need to develop historical and philosophical archiving and source studies in Russia, to include this set of subjects into the system of training historians of philosophy, and also about the need to coordinate the joint efforts of historians of Russian philosophy towards the formation of an archive of Russian philosophy as a significant and publicly available mapped resource. The results obtained in the course of the study should contribute to the emergence of the history of Russian philosophy as a dynamically developing branch of Russian science to a qualitatively new source study and methodological level, necessary for solving the large-scale research tasks, related, in particular, to the scientific preparation of academic collections of works by Russian philosophers and the development of modern fundamental history of Russian philosophy. (shrink)

The objective of analysis is new opportunities in the study of self-awareness, which became possible through the use of an interdisciplinary approach. This approach allows to solve number of conceptual and methodological problems in psychology and psychiatry. The general development of psychiatry in the 20th and early 21st centuries was to improve diagnosis and therapy based on objectively measured indicators. There is a very superficial development of the phenomenology of self-awareness disorders as a result. The interdisciplinary point of view may (...) be the beginning of new theoretical studies of self-awareness in philosophy, as well as provoke pragmatic conclusions for psychological and psychiatric science. Authors claim that the delimitation of the methodological tools of various sciences in the study of self-awareness is unnecessary in principle. interdisciplinary view should be formed by philosophers. The phenomenology of Karl Jaspers and his concept of self-awareness in this sense are heuristically attractive. The authors propose a working model of self-awareness, based on the phenomenological approach of Jaspers, on the ideas of his followers, and also abandoning the disciplinary view of the subject. In this model self-awareness is described through its specific functions. That may be pragmatically useful for mental health professionals: psychiatrists, psychologists and psychotherapists and it may be interesting to philosophers using phenomenological analysis. (shrink)

High‐precision tumor targeting with conventional therapeutics is based on the concept of the ideal drug as a “magic bullet”; this became possible after techniques were developed for production of monoclonal antibodies (mAbs). Innovative DNA technologies have revolutionized this area and enhanced clinical efficiency of mAbs. The experience of applying small‐size recombinant antibodies (monovalent binding fragments and their derivatives) to cancer targeting showed that even high‐affinity monovalent interactions provide fast blood clearance but only modest retention time on the target antigen. Conversion (...) of recombinant antibodies into multivalent format increases their functional affinity, decreases dissociation rates for cell‐surface and optimizes biodistribution. In addition, it allows the creation of bispecific antibody molecules that can target two different antigens simultaneously and do not exist in nature. Different multimerization strategies used now in antibody engineering make it possible to optimize biodistribution and tumor targeting of recombinant antibody constructs for cancer diagnostics and therapy. BioEssays 30:904–918, 2008. © 2008 Wiley Periodicals, Inc. (shrink)

Personal branding has become an important concept in management literature in recent years. Yet, with more than 100 scholarly papers published on the concept to date, it has developed into a fragmented area of research with a diversity of definitions and conceptual boundaries. This paper posits that this heterogeneity of extant research impedes theoretical and empirical advancement. To strengthen the foundation for future work, we review the extant literature and offer an integrative model of personal branding. Through our systematic literature (...) review we identify the key attributes of the construct, establish its clarity by comparing it with similar concepts in its nomological network, and suggest the definitions of personal branding and personal brand based on the reviewed literature. Further, we propose a theoretical model of personal branding summarizing the findings from the reviewed papers. The proposed model outlines the trends conducive to personal branding, as well as its drivers, processes, and outcomes. Finally, we discuss ethical implications of personal branding for both scholarly work and practice. In conclusion, we outline a further research agenda for studying personal branding as a critical career and organizational behavior activity in contemporary working environment. (shrink)

Sobre la base de la teoría de “los mejores” de J. Ortega y Gasset el autor trató de investigar el papel de los estratos superiores de la sociedad, de la élite nacional en la modernización del régimen político en los principios de la democracia y la poliarquía. Fue revelado el papel en los procesos del gobierno y la administración del poder político y ejecutivo del aparato estatal, que consiste en los funcionarios públicos, profesional y moralmente preparados y capaces asegurar el (...) funcionamiento sostenible y soberano de las instituciones del Estado. En Rusia en el inicio del 2012 se comenzón las actividades socio-políticas llamadas en la ciencia política como la tecnología “de nacionalizaciόn” de las élites. Se produce una armonización de los intereses de los grupos políticos y empresariales de alto nivel social con los intereses del Estado y la sociedad civil. Fue realizado el análisis comparativo del impacto de las élites políticas de España y Rusia sobre la estabilidad política para garantizar el desarrollo socio-económico soberano de sus países. En la soberanía del Estado se refleja la plenitud de la autoridad governamental de los grupos sociales más altos, la élite nacional. Por separado se destacó la función de la élite político-militar como un aparato coercitivo legítimo, que asegura el bienestar del Estado democrático. Los modelos actuales de los regímenes políticos democráticos – no es una meta, sino un instrumento para lograr el bienestar del Estado y nación. Los acontecimientos en Rusia contemporánea comproban la actualidad científica de las obras del gran pensador J.Ortega y Gasset. (shrink)

This volume examines some of the most contentious social justice issues present in the corpus of Augustine's writings. Whether one is concerned with human trafficking and the contemporary slave trade, the global economy, or endless wars, these essays further the conversation on social justice as informed by the writings of Augustine of Hippo.

We exploit properties of certain directed graphs, obtained from the families of sets with special effective enumeration properties, to generalize several results in computable model theory to higher levels of the hyperarithmetical hierarchy. Families of sets with such enumeration features were previously built by Selivanov, Goncharov, and Wehner. For a computable successor ordinal α, we transform a countable directed graph into a structure such that has a isomorphic copy if and only if has a computable isomorphic copy.A computable structure is (...) categorical if for all computable isomorphic copies of , there is an isomorphism from onto , which is . We prove that for every computable successor ordinal α, there is a computable, categorical structure, which is not relatively categorical. This generalizes the result of Goncharov that there is a computable, computably categorical structure, which is not relatively computably categorical.An additional relation R on the domain of a computable structure is intrinsically on if in all computable isomorphic copies of , the image of R is . We prove that for every computable successor ordinal α, there is an intrinsically relation on a computable structure, which not relatively intrinsically . This generalizes the result of Manasse that there is an intrinsically computably enumerable relation on a computable structure, which is not relatively intrinsically computably enumerable.The dimension of a structure is the number of computable isomorphic copies, up to isomorphisms. We prove that for every computable successor ordinal α and every n≥1, there is a computable structure with dimension n. This generalizes the result of Goncharov that there is a structure of computable dimension n for every n≥1.Finally, we prove that for every computable successor ordinal α, there is a countable structure with isomorphic copies in just the Turing degrees of sets X such that relative to X is not . In particular, for every finite n, there is a structure with isomorphic copies in exactly the non- Turing degrees. This generalizes the result obtained by Wehner, and independently by Slaman, that there is a structure with isomorphic copies in exactly the nonzero Turing degrees. (shrink)

The article is a philosophical reflection of the author, caused by M.N. Epstein’s book “Children’s Questions: Dialogues” (Moscow, 2020). The book presents more than 300 children’s questions, covering the most diverse facets of being: from the universe as a whole to psychological, moral, social, aesthetic problems. The idea of the book is to engage children and adults in a general conversation about the most important phenomena of the universe. The author of the article weaves the material of the book into (...) the outline of existential comprehension of truth. (shrink)

Introduction. N. A. Berdyaev’s many-sided philo- sophical interests and his indefatigability in creative activity contributed to the development of an original worldview system, in which eschatological ideas were the basic part. The authors consider the assessment of these ideas by the outstanding his- torian of Russian philosophy V.V. A. Berdyaev, the significance of which is enhanced due to the fact that it was given not only by a historian of thought, but also by the creator of his own and generally (...) complete philosophical system, based, like the philosophy of N. A. Berdyaev, on the ideological foundation of Orthodoxy. The purpose of the study. The authors attempt to identify the causes and motives for the discrepancy between N. A. Berdyaev’s eschatological ideas and the traditional Christian understanding of the “end of history”, which V. V. Zenkovsky strictly adhered to. Methods. As a general philosophical methodology, the authors use a personalistic approach, which was followed by both N. A. Berdyaev and V. V. Zenkovsky. The main premise of this approach is to affirm the free-creative activity of a person who, following his inner impulses is capable of changing the surrounding reality, both social and natural. The study also uses general scientific methods — analy- sis, synthesis, comparison, generalization. Scientific novelty of the research. The authors’ conclusions regarding the fact that N. A. Berdyaev did not overcome the evolutionist historiosophical paradigm, which has retained its significance in Russian metaphysics since the publication of the early works of V. S. Solovyov, the founder of this direction, have scientific novelty. Results. The eschatology of N. A. Berdyaev should be considered transitional from immanent (evolu- tionary) to transcendent, since elements of panthe- ism were preserved in it. V. V. Zenkovsky drew attention to this, noting that the entire religious world of N. A. Berdyaev bears the “fatal seal” of religious immanentism. Due to the inconsistency of his beliefs with the general worldview of Christian transcendentism, which never essentially brought the Creator and creation closer together, V.V. Zenkovsky avoided assessing N.A. Berdyaev as an Orthodox philosopher. (shrink)

Primary headaches are highly prevalent and represent a major cause of disability in young adults. Neurofeedback is increasingly used in the treatment of chronic pain; however, there are few studies investigating its efficacy in patients with headaches. We report the results of a cross-over sham-controlled study on the efficacy of neurofeedback in the prophylactic treatment of tension-type headache. Participants received ten sessions of infra-low frequency electroencephalographic neurofeedback and ten sessions of sham-neurofeedback, with the order of treatments being randomized. The study (...) also included a basic psychotherapeutic intervention — a psychoeducational session performed before the main study phases and emotional support provided throughout the study period. The headache probability was modeled as a function of the neurofeedback and sham-neurofeedback sessions performed to date. As a result, we revealed a strong beneficial effect of neurofeedback and no influence of the sham sessions. The study supports the prophylactic use of infra-low frequency neurofeedback in patients with TTH. From a methodological point of view, we advocate for the explicit inclusion of psychotherapeutic components in neurofeedback study protocols. (shrink)

This text is a polemic against the 2023 article by Sergey N. Gradirovsky who wrote about the present-day relevance of Immanuel Kant’s concept of enlightenment and challenged the idea of the modern human being as a child who needs an external guardian or guide to control his behaviour. In my polemic with Gradirovksy I point out that in addition to “self-incurred immaturity” Kant writes about the historical “immaturity” of savage or backward peoples. I also argue that for Kant “maturity” (...) carries not only biological but also socio-historical connotations. I show that in the modern world Kant’s idea of the social or even historical maturity of the modern human acquires serious problematisation which was shown to be possible and inevitable in the article “What Is Enlightenment?” (1784) and its notion of the historicity of enlightenment, i.e. the very strategy of modernity is possible only when humankind reaches a certain historical age. Using as a point of departure the ideas of the French philosopher Michel Foucault, I maintain that the Kant­ian conception of enlightenment is at once ironic and tragic. It is ironic because it does not rule out that its main thesis on the historical maturity of the human being may turn out to be wrong. It is tragic because its main thrust is “heroisation of the present”, i.e. a readi­ness to resist the temptation of being absorbed by the future, which takes on added relevance in view of the virtualisation of reality. (shrink)

We examine the reverse mathematical strength of a variation of Hindman’s Theorem (HT) constructed by essentially combining HT with the Thin Set Theorem to obtain a principle that we call thin-HT. This principle states that every coloring c:N→N has an infinite set S⊆N whose finite sums are thin for c, meaning that there is an i with c(s)≠i for all nonempty sums s of finitely many distinct elements of S. We show that there is a computable instance of thin-HT such (...) that every solution computes ∅′, as is the case with HT, as shown by Blass, Hirst, and Simpson (1987). In analyzing this proof, we deduce that thin-HT implies ACA0 over RCA0+IΣ20. On the other hand, using Rumyantsev and Shen’s computable version of the Lovász Local Lemma, we show that there is a computable instance of the restriction of thin-HT to sums of exactly 2 elements such that any solution has diagonally noncomputable degree relative to ∅′. Hence there is a computable instance of this restriction of thin-HT with no Σ20 solution. (shrink)

The paper enters contemporary discourse concerning the examination of history of Russian philosophy, which initiates a new reading of the Russian thinkers’ works. These contemporary examinations problematize the phenomenon of so called intellectual doubles as well. The contribution proceeds from the definition of these issues which was published in journal Problems of Philosophy by M. A. Maslin in 2013. In this work, Maslin mentions A. I. Herzen among the examples of intellectual doubles phenomenon, who is one of the founders of (...) the Russian Narodism. Following from this basis, the contribution shifts an attention toward issues of intellectual doubles in the context of the Russian Narodism. The work represents an endeavour to deepen the existing problematization of this phenomenon on the basis of examination the N. K. Mikhailovsky’s creative legacy. There can be found two faces in works of this Narodnik thinker. The first one can be figuratively designed as a Petersburgian and the second one as a Yaltian. These designations are borrowed from the notes of Sergey Elpatevsky, who had been Mikhailovsky’s friend. The two faces express the specificity of the problem of doubleness in Mikhailovsky and his qualitative shift in relation to contemporary examinations of the reflected phenomenon. (shrink)

On the eminence and dignity of parents; in the light of Koran and Hadith (Islamic traditions).

Aproximación al pensamiento de Rodolfo Kusch -- Canto e identidad en el Martín Fierro según Carlos Astrada y Rodolfo Kusch -- Donde el barro se subleva -- La rehabilitación del saber seminal como camino hacia una mística popular -- Kusch y el impulso social de nuestra época -- La barbarización de la civilización, una grieta de antaño -- ¿De dónde pensarnos?